Adding a certain compound to certain chemical reactions, such as: 1224944-77-7, Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1224944-77-7, blongs to pyrimidines compound. Quality Control of Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate
[0347] Step 4: To a solution of 5-Chloro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester (100 mg, 0.44 mmol) and 11-iD (110 mg, 0.41 mmol) in anhydrous THF (5.0 mL) at – 78C, NaH (60%, 17 mg, 0.44 mmol) was added. The mixture was allowed to warm to rt and stilTed for 8 hours until a good amount of desired product was formed. The mixture was then diluted with water/ice and extracted with DCM (3×20 mL). The organic layer was dried over Na2SO4, concentrated and purified by silica gel column chromatography to afford 1 1-1E as a yellow liquid (20 mg, 0.045 mmol, 6%), which is used directly in the next step.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1224944-77-7, its application will become more common.
Reference:
Patent; TP THERAPEUTICS, INC.; CUI, Jingrong Jean; LI, Yishan; ROGERS, Evan W.; ZHAI, Dayong; WO2015/112806; (2015); A3;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia