Reference of 1337962-47-6, Adding some certain compound to certain chemical reactions, such as: 1337962-47-6, name is 5-Bromo-2,6-di(1H-pyrazol-1-yl)pyrimidin-4-amine,molecular formula is C10H8BrN7, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1337962-47-6.
A mixture of 8.9 mg (13.1 mu?iotaomicron) of Pd-PEPPSI-IPr-catalyst, 0.1 g (0.33 mmol) of 5-bromo-2,6- di(lH-pyrazol-l-yl)pyrimidin-4-amine (Example 1), 0.1 g (0.65 mmol) of cesium fluoride and activated, crushed 4A molecular sieves (33 mg) in a glass vial was purged with argon and 1 ml of dioxane was added. 0.15 (0.39 mmol) of 2-tributylstannylthiazole was then added and the reaction was stirred at 80C for 24 h. The mixture was filtered throw celite/CsF. The solvent was removed in vacuum. The residue was purified by column chromatography with silica gel and methylene chloride and methanol as eluent to give 47.9 mg (47.2 %) of the desired product.1H-RM (300 MHz, DMSO-d6): delta = 6.57 (dd, 1H), 6.58 (dd, 1H), 7.34 (d, 1H), 7.52 (s, 1H), 7.81 (d, 1H), 7.86 (d, 1H), 7.92 (d, 1H), 8.41 (s, 1H), 8.51 (d, 1H), 8.60 (d, 1H).
According to the analysis of related databases, 1337962-47-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PALOBIOFARMA, S.L.; CAMACHO GOMEZ, Juan Alberto; CASTRO-PALOMINO LARIA, Julio Cesar; WO2011/121418; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia