Electric Literature of 157335-97-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 157335-97-2 as follows.
To a solution of 5-(furo[3,2-c]pyrid in-4-yloxy)-2-(4,4,5,5-tetramethyl-1 ,3,2-d ioxaborolan2-yl)benzyl acetate (C34)(82 mg, 0.20 mmol) in 1,4-dioxane (10 mL)were added 5-bromo-4,6- dimethylpyrimidine (41 mg, 0.22 mmol), potassium carbonate (83 mg, 0.6 mmol), [1,1?-bis(diphenylphosphino)ferrocene]dichloropalladium(ll) (44 mg, 0.060 mmcl) and water (5 drops) at room temperature. The reaction mixture was degassed with nitrogen for 5 minutes, thensubjected to microwave irradiation at 12000 for 50 minutes. After filtration of the reactionmixture, the filtrate was concentrated in vacuo; purification was carried out by preparative thinlayer chromatography to give the product. Yield: 28 mg, 0.072 mmol, 36%. LCMS m/z 389.9(M+H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,157335-97-2, its application will become more common.
Reference:
Patent; PFIZER INC.; COE, Jotham, Wadsworth; ALLEN, John, Arthur; DAVOREN, Jennifer, Elizabeth; DOUNAY, Amy, Beth; EFREMOV, Ivan, Viktorovich; GRAY, David, Lawrence, Firman; GUILMETTE, Edward, Raymond; HARRIS, Anthony, Richard; HELAL, Christopher, John; HENDERSON, Jaclyn, Louise; MENTE, Scot, Richard; NASON, Deane, Milford, II; O’NEIL, Steven, Victor; SUBRAMANYAM, Chakrapani; XU, Wenjian; WO2014/72881; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
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