Application of 16234-10-9 , The common heterocyclic compound, 16234-10-9, name is Thieno[3,2-d]pyrimidin-4(3H)-one, molecular formula is C6H4N2OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a mixture of H2SO4 (20 mL) and HNO3 (15 mL) was added compound 3 (9.7 g, 0.064 mol) slowly under ice-bath condition. Then, the reaction mixture was heated to room temperature. When the staring material was consumed, the mixture was poured into the ice-water carefully, and the yellow solid was formed, followed by filtration. The cakewas washed with water for three times, dried to afford the desired compound 4, 10.8 g as yellow solid in 86% yield. 1H NMR (400 MHz, DMSO-d6) delta 13.00 (s, 1H), 9.33 (s, 1H), 8.35 (s, 1H); MS (ESI) m/z 195.9 [M+H]+.
The synthetic route of 16234-10-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wang, Jiang; Su, Mingbo; Li, Tingting; Gao, Anhui; Yang, Wei; Sheng, Li; Zang, Yi; Li, Jia; Liu, Hong; European Journal of Medicinal Chemistry; vol. 128; (2017); p. 293 – 299;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia