Electric Literature of 17326-27-1, Adding some certain compound to certain chemical reactions, such as: 17326-27-1, name is 2-Chloro-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde,molecular formula is C10H7ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17326-27-1.
General procedure: To a stirred solution of 2-chloro-4-oxo-4H-pyrido [1,2-a]pyrimidine-3-carbaldehyde (100mg, 0.479mmol) in THF (3mL) was added benzylamine (0.058mL, 0.527mmol) and TEA (0.1mL, 0.719mmol). The reaction mixture was stirred at 70C for 3h. after the mixture was concentrated, 1N aqueous HCl solution in THF (1/3 ratio, 4mL). The reaction mixture was stirred at 70C for 1h. after reaction was completed, the mixture was evaporated and neutralized to approximately pH 7 by adding 1N NaOH. The pale solid was collected by filtration and washed with H2O to give 5a (117mg, 87%) as a brown solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 17326-27-1, 2-Chloro-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Park, Dong-Sik; Jo, Eunji; Choi, Jihyun; Lee, MyungEun; Kim, Soohyun; Kim, Hee-Young; Nam, Jiyon; Ahn, Sujin; Hwang, Jong Yeon; Windisch, Marc Peter; European Journal of Medicinal Chemistry; vol. 140; (2017); p. 65 – 73;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia