Electric Literature of 302964-08-5, Adding some certain compound to certain chemical reactions, such as: 302964-08-5, name is 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide,molecular formula is C16H13Cl2N5OS, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 302964-08-5.
In a 250 mL two-necked flask equipped with a reflux condenser,Compound I-6 (10.00 g, 25.4 mmol) was added at room temperature,Was dissolved in DMSO, 1-Boc-3-aminopyrrolidine (6.6 g, 35.6 mmol)DIPEA (N, N-diisopropylethylamine), 8.4 mL, 50.8 mmol) was slowly added under a nitrogen stream.Stir for 1 hAnd then heated to 80 C.TLC monitoring reaction. After completion of the reaction, the mixture was cooled to room temperature, water was added thereto, and the mixture was suctioned and washed with ice-cold water and beat with DCM to give a pure white intermediate. The intermediateTransfer to 10 mL of 30% TFA in methylene chloride and the reaction was stirred at room temperature, TLC was monitored, the reaction was completed, steamed to dryness, residualThe residue was washed three times with saturated sodium bicarbonate solution, filtered and the cake was dried to give 7.7% of I-8 in 68% yield.
According to the analysis of related databases, 302964-08-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Chinese Academy Of Sciences Guangzhou Bio-pharmaceutical And Health Institute; Zhang Jiancun; Liu Lu; Chen Chaonan; Duan Anna; Tu Zhengchao; Yao Guoqiang; (42 pag.)CN106749223; (2017); A;,
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