Related Products of 13036-57-2 ,Some common heterocyclic compound, 13036-57-2, molecular formula is C5H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution containing 37 g (188 mmol) of methyl 3,5-bis(methyloxy)benzoate and 300 mL of THF at 00C was added 395 mL (395 mmol) of a 1.0 M solution of LHMDS in THF. To this mixture, a solution containing 29 g (226 mmol) of 2-chloro-4- methylpyrimidine and 100 mL was added dropwise over about 30 min. The reaction mixture was allowed to stir for an additional 30 min and quenched by the addition of 100 mL of MeOH. The solvents were removed under reduced pressure and the residue was partitioned between EtOAc and water. The combined organic layers were dried over MgSO4 and filtered, washing the filter cake with copious amounts of EtOAc and DCM to dissolve precipitated product. The solvents were removed under reduced pressure and the resulting orange solid was triturated from EtOAc to give 46.5 g (85%) of 1-[3,5-bis(methyloxy)phenyl]-2-(2-chloro-4-pyrimidinyl)ethanone as a light tan solid, which exists as a mixture of ketone and enol tautomers: MS (ESI): 293.29 (M+H+).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13036-57-2, its application will become more common.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/32667; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia