Reference of 2915-16-4 ,Some common heterocyclic compound, 2915-16-4, molecular formula is C16H11ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
NaH (1.9 mg, 42.1 mmol) was dissolved in dimethylformamide (DMF) in a flask and the mixture was stirred. Compound 5-2 (7.0 g, 27.2 mmol) was dissolved in DMF in a flask and added to the stirred NaH solution, and the mixture was stirred for 1 hr. 2-Chloro-4,6-diphenylpyrimidine (8.7 g, 32.6 mmol) was dissolved in DMF in a flask and stirred. The mixture stirred for 1 hr was added thereto and then stirred at room temperature for 24 hrs. After completing the reaction, the resulting solid was filtered, washed with EA, and purified by column chromatography to obtain compound H-33 (3.5 g, 25 %).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2915-16-4, 2-Chloro-4,6-diphenylpyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ROHMANDHAASELECTRONICMATERIALSKOREA LTD; LEE, KYUNG-JOO; YOON, SEOK-KEUN; KIM, CHI-SIK; KIM, HYUN; LEE, SEON-WOO; JUNG, SO-YOUNG; LEE, SU-HYUN; YANG, JEONG-EUN; KIM, YOUNG-KWANG; CHO, YOUNG-JUN; PARK, KYOUNG-JIN; JANG, SUNG-WOO; (50 pag.)TW2016/5841; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia