As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine, molecular formula is C16H11ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 2915-16-4
Intermediates in a nitrogen environment I-3 (10 g, 23.1 mmol)Was dissolved in 0.1 L of tetrahydrofuran (THF), and the solution was added thereto by the Tokyo Chemical Industry (http://www.tcichemicals.com/)2-chloro-4,6-diphenylpyrimidine (6.16 g, 23.1 mmol)And tetrakis (triphenylphosphine) palladium (0.27 g, 0.23 mmol)And the mixture was stirred. Saturated water-saturated potassuim carbonate (7.98 g, 57.8 mmol) was added and heated at 80 C for 10 hours to reflux. After completion of the reaction, water was added to the reaction mixture, and the mixture was extracted with dichloromethane (DCM). The extract was dried over anhydrous MgSO 4, filtered, and concentrated under reduced pressure. The residue thus obtained was separated and purified by flash column chromatography to obtain Compound 2 (10.5 g, 85%).
With the rapid development of chemical substances, we look forward to future research findings about 2915-16-4.
Reference:
Patent; Samsung SDI Co., Ltd; Lee Han-il; Ryu Eun-seon; Jeong Seong-hyeon; Han Su-jin; Kang Dong-min; Shin Chang-ju; Lee Byeong-gwan; Jeong Su-yeong; (46 pag.)KR2018/123660; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia