As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 22536-63-6, name is 2-Chloro-4-methoxypyrimidine, molecular formula is C5H5ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 22536-63-6
2-Bromopyridine or 2-chloropyrimidine (2equiv.), 5-amino-2-substitutedphenol (lequiv) and 37% HCl solution (2equiv) in 10% aqueous EtOH solution (0.2M) was stirred at 9O0C for 24h. The reaction mixture was diluted with AcOEt and washed with 5% aqueous K2CO3 solution and brine. The organic phase was dried over Na2SO4, concentrated and the crude product was purified by flash chromatography on silica gel.; Following the general procedure for the synthesis of 2-R-5-(heteroaryl-2-ylamino)phenol, 2- chloro-4-methoxypyrimidine (44 mg, 0.30 mmol) and 4-amino-o-cresol (37 mg, 0.30 mmol) in 10% aqueous EtOH (2 mL) was heated at 90 0C for 18h. The title compound was obtained in 21 % yield a (14 mg) and used for the next step without addittional purification. 1H NMR (500 MHz, CD3OD) £8.06 (d, J= 5.8 Hz, IH), 7.25 (d, J= 2.0 Hz, IH), 6.98 (d, J = 8.2 Hz, IH), 6.92 (dd, J= 8.2, 2.0 Hz, IH), 6.18 (d, J= 5.8 Hz, IH), 3.97 (s, 3H), 2.16 (s, 3H); 13C NMR (125 MHz, CD3OD) £ 172.1, 162.1, 159.1, 156.8, 140.3, 131.9, 120.2, 112.9, 108.5, 99.8, 54.5, 16.1.
With the rapid development of chemical substances, we look forward to future research findings about 22536-63-6.
Reference:
Patent; YALE UNIVERSITY; WO2007/38387; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia