Application of 7627-44-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7627-44-3, name is 2,4-Dichloro-5-(iodomethyl)pyrimidine, molecular formula is C5H3Cl2IN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 2,4-dichloro-5-(iodomethyl)pyrimidine 2 (7.0 g, 24.2 mmol), 2,6- dimethylaniline (3.8 g, 31.4 mmol), K2CO3 (5.0 g, 36.2 mmol) in acetone (60 mL) was stirred at 55 C overnight. The solvent was removed and the residue was extracted with EtOAc (150 mL x 3). The combined organic phase was washed with brine (80 mL x 3), dried with Na2S04, filtered, and concentrated. The residue was purified by column chromatography on silica gel (petroleum ether / EtOAc = 8/1, 4/1, 1/1) to get N-((2,4-dichloropyrimidin-5- yl)methyl)-2,6-dimethylaniline 3 as a light brown solid (4.5 g, yield 66%). LCMS (m/z): 282.3 [M + H]+.
According to the analysis of related databases, 7627-44-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; THE GENERAL HOSPITAL CORPORATION; DANA-FARBER CANCER INSTITUTE, INC.; MURAKAMI, Ryo; FISHER, David, E.; MUJAHID, Nisma; GRAY, Nathanael, S.; (0 pag.)WO2018/160774; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia