Reference of 160199-05-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 160199-05-3, name is 2,4-Dichlorobenzo[4,5]thieno[3,2-d]pyrimidine. A new synthetic method of this compound is introduced below.
Starting material2,4-dichlorobenzo [4,5] thieno [3,2-d] pyrimidine(32 g, 125.6 mmol)4,4,5,5-tetramethyl-2- (naphthalen-2-yl) -1,3,2-dioxaborolane(35 g, 138 mmol), Pd (PPh3) 4 (5.80 g, 5.02 mmol), K2CO3 (52 g, 376.41 mmol), THF (440 ml), water (220 ml)And the mixture is heated under reflux at 80 C to 90 C.When the reaction is complete, dilute with distilled water at room temperature and extract with methylene chloride and water.The organic layer was dried over MgSO4 and concentrated. The resulting compound was purified by silicagel column and recrystallizationSub 2-61 (19.58 g, yield: 45%) was obtained
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,160199-05-3, its application will become more common.
Reference:
Patent; Duksan Neolux Co.,Ltd.; Jeong Ho-yeong; Ryu Jae-deok; Jeon Jin-bae; Cho Min-ji; (47 pag.)KR2019/1967; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia