Application of 2802-62-2, Adding some certain compound to certain chemical reactions, such as: 2802-62-2, name is 4,6-Difluoropyrimidine,molecular formula is C4H2F2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2802-62-2.
4-Amino-phenol (0.135 g, 1.21 [MMOL)] is added in one portion to a suspension of NaH (60% free-flowing powder moistened with oil, 58.2 mg, 1.45 mmol, 1.2 equiv) in dioxane abs. (1.4 mL), under an argon atmosphere. When hydrogen evolution subsides, a solution of 4,6- [DIFLUORO-PYRIMIDINE] (0.141 g, 1.21 [MMOL)] in dioxane (0.4 mL) is added. The resulting dark mixture is stirred for 1.5 h at rt, quenched by addition of MeOH (2 mL) and concentrated in vacuo. After addition of CH2CI2, the resulting suspension is filtered and concentrated in vacuo. The residue is purified by silica gel column chromatography [(CH2CI2/ET2O,] 90/10, then 85/15) to afford the title compound as a white solid : ES-MS: 204.0 [M+H] [+] ; single peak at [TR=] 4. 96 min (System 2); Rf = 0.30 [(CH2CI2/ET20,] 85/15).
According to the analysis of related databases, 2802-62-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2003/99771; (2003); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia