Electric Literature of 33034-67-2, Adding some certain compound to certain chemical reactions, such as: 33034-67-2, name is 2-Chloro-4-(trifluoromethyl)pyrimidine,molecular formula is C5H2ClF3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33034-67-2.
Step 1: To a solution of (R)-3-isopropylpiperazin-2-one hydrochloride (2.61 g, 14.62 mmol) and iPr2NEt (7.60 mL, 43.86 mmol) in DMF (20 mL) was added a solution of 2-chloro-4- (trifluoromethyl)pyrimidine (3.47 g, 19.00 mmol) in DMF (2 mL). The resulting solution was stirred at 100 ¡ãC under N2 for 3 h at which point the reaction was deemed complete by LC- MS. Sat. aq. NH4C1 (30 mL) was added to quench the reaction, followed by addition of EtOAc (30 mL). The EtOAc layer was separated and the aqueous layer was extracted with EtOAc (3 x 20 mL). The EtOAc layers were combined, dried using Na2S04 and evaporated to give nearly pure crude product. Purification on a silica cartridge using ISCO FCC eluting with 100percent EtOAc gave 4.03 grams of (R)-3-isopropyl-4-(4-(trifluoromethyl)pyrimidin-2- yl)piperazin-2-one (96percent) as a slightly orange thick oil.LC-MS m/z 289.17 [M + H]+ 1H NMR (CDCI3, 400MHz): delta 8.52 (d, / = 4.8 Hz, 1H), 6.82 (d, / = 4.4 Hz, 1H), 6.56 (br, 1H), 5.20 (d, / = 6.8 Hz, 1H), 4.83-4.77 (m, 1H), 3.55-3.37 (m, 3H), 2.49-2.41 (m, 1H), 1.15 (d, J = 6.8 Hz, 3H), 1.04 (d, / = 6.8 Hz, 3H).
According to the analysis of related databases, 33034-67-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; VITAE PHARMACEUTICALS, INC.; DONG, Chengguo; FAN, Yi; LEFTHERIS, Katerina; LOTESTA, Stephen; SINGH, Suresh, B.; TICE, Colin; ZHAO, Wei; ZHENG, Yajun; ZHUANG, Linghang; WO2013/138565; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia