Reference of 36314-98-4 ,Some common heterocyclic compound, 36314-98-4, molecular formula is C5H4N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
40-48wt.% aqueous ammonium sulfide (8.27ml, 48.5mmol) was added to a mixture of 57 (5.3g, 44.1mmol), triethylamine (6.14ml, 44.1mmol), and pyridine (28.8ml, 353mmol) and the resulting suspension was stirred at 52C for 2h. The mixture was concentrated under reduced pressure and H2O was added to the residue. The mixture was chilled to 0C and the resulting precipitate was removed by filtration to deliver 2-aminopyrimidine-4-carbothioamide (5.5g, 35.7mmol, 80% yield) as a yellow solid. 1H NMR (400MHz, DMSO-d6) delta ppm 10.23 (br. s, 1H), 9.58 (br. s, 1H), 8.42 (d, J=4.9Hz, 1H), 7.35 (d, J=4.9Hz, 1H), 6.80 (br. s, 2H). MS (ESI, pos. ion) m/z: 155.1 (M+1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 36314-98-4, 2-Amino-4-cyanopyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Reichelt, Andreas; Bailis, Julie M.; Bartberger, Michael D.; Yao, Guomin; Shu, Hong; Kaller, Matthew R.; Allen, John G.; Weidner, Margaret F.; Keegan, Kathleen S.; Dao, Jennifer H.; European Journal of Medicinal Chemistry; vol. 80; (2014); p. 364 – 382;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia