Adding a certain compound to certain chemical reactions, such as: 14160-93-1, 4-Amino-6-chloropyrimidine-5-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 14160-93-1, blongs to pyrimidines compound. Computed Properties of C5H4ClN3O
4-benzyloxy-3-chloro-phenylamine Compound 1c (8.9 g, 38 mmol) was added to a solution of Compound 1b (6.0 g, 38 mmol) and Et3N (10.6 mL, 76 mmol) in DMSO (38 mL, 1M). The mixture was warmed at 100 C. for 3 hrs. The reaction mixture was cooled, then diluted with H2O and extracted with EtOAc (3¡Á). The organic extract was washed with H2O (4¡Á), concentrated onto SiO2 (30 g) and purified via column chromatography (Horizon, 65+, 60 to 100% EtOAc/hexanes) to afford 4-amino-6-(4-benzyloxy-3-chloro-phenylamino)-pyrimidine-5-carbaldehyde Compound 14 (8.29 g, 61%) as a yellow solid. H E NMR (400 Mhz, CD3OD, warm) delta 10.15 (s, 1H), 8.05 (s, 1H), 7.77 (d, J=2.4 Hz, 1H), 7.48 (d, J=76 Hz, 2H), 7.38 (m, 4H), 7.11 (d, J=8.8 Hz, 1H), 5.18, (s, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14160-93-1, its application will become more common.
Reference:
Patent; Connolly, Peter J.; Hughes, Terry V.; Wetter, Steven K.; US2009/111810; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia