Electric Literature of 4994-86-9, Adding some certain compound to certain chemical reactions, such as: 4994-86-9, name is 4-Chloro-2-methylpyrimidine,molecular formula is C5H5ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4994-86-9.
To a mixture of 4-chloro-2-methyl-pyrimidine (10.0 g, 7.8 mmol) and AIBN (5.1 g, 31.1 mmol) in CCl4 (100 mL) was added NBS (16.6 g, 93.3 mmol) at 25 C. and the mixture was stirred at 80 C. for 16 hrs. LCMS showed the reaction was completed. The reaction mixture was cooled down to room temperature, poured into H2O (150 mL) and extracted with DCM (80 mL¡Á2). The organic layers were combined and washed with brine (80 mL¡Á2), dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give 2-(bromomethyl)-4-chloropyrimidine (1.7 g, yield 10.5%) as yellow oil. 1H NMR (400 MHz, CDCl3) delta=8.64 (d, J=5.6 Hz, 1H), 7.29 (d, J=5.2 Hz, 1H), 4.56 (s, 2H).
According to the analysis of related databases, 4994-86-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ESSA Pharma, Inc.; Zhou, Han-Jie; Virsik, Peter; (216 pag.)US2020/123117; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia