Extracurricular laboratory: Synthetic route of 4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,582313-57-3, its application will become more common.

Application of 582313-57-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 582313-57-3 as follows.

This compound is synthesized using a procedure such as that described by ?.Vorbruggen and U. Niedballa in J. Org. Chem., 39: 3654-3660 (1974). The 4-chloro-5-fluoro-7H- pyrrolo[2,3-d]pyrimidine (1?) used in this transformation is prepared following the procedure described by A. B. Eldrup, et al. in J. Med. Chem.. 47: 5284 (2004).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,582313-57-3, its application will become more common.

Reference:
Patent; MERCK & CO., INC.; WO2006/65335; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia