The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3435-25-4, name is 4-Chloro-6-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4-Chloro-6-methylpyrimidine
To a mixture of (S)-i sopropyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-2-methyl-6-(3 -(tetrahydro-2H-pyran-4-yl)propyl)-5 -(1,2,3 ,4-tetrahydroi soquinolin-6-yl)pyridin-3 -yl)acetate, 2 HC1 (0.01 g, 0.014 mmol) and 4-chloro-6-methylpyrimidine (0.01 g, 0.078mmol) in dioxane (0.5 mL) was added potassium carbonate (0.02 g, 0.145 mmol) andheated in a seal vial at 100 C for 18 h. Then, filtered off the solid, removed the solvent,and residue was treated with EtOH (1 ml) and sodium hydroxide (0.550 mg, 0.014 mmol)at 85 C for 2 h. Then, cooled and purified by prep HPLC to afford (S)-2-(tert-butoxy)-2- (4-(chroman-6-yl)-2-methyl-5 -(2-(6-methylpyrimidin-4-yl)- 1,2,3 ,4-tetrahydroi soquinolin6-yl)-6-(3 -(tetrahydro-2H-pyran-4-yl)propyl)pyridin-3 -yl)acetic acid (0.0027 g, 3.64 tmol, 26.5 % yield) LCMS (M+H) = 705.3.
With the rapid development of chemical substances, we look forward to future research findings about 3435-25-4.
Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; KADOW, John F.; NAIDU, B. Narasimhulu; TU, Yong; (133 pag.)WO2017/29631; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia