Electric Literature of 3438-46-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3438-46-8, name is 4-Methylpyrimidine, molecular formula is C5H6N2, molecular weight is 94.1145, as common compound, the synthetic route is as follows.
[00125] In one example, Compound iii was prepared by reacting 4- (bis(hydroxyethyl)amino)benzaldehyde (234 mg, 1.12 mmol) with of -4-methylpyrimidine (112 mu,, 1.23 mmol) and of potassium tert-butoxide (376 mg, 3.35 mmol) in N,N-dimethyl formamide (10 mL) for 12 hours at 80 C. The resulting mixture was cooled to ambient temperature and filtered through celite and concentrated. Compound iii was isolated as the major component of a mixture by silica gel chromatography using an ethyl acetate/methanol/hexane solvent system. (E)-2,2′-{[4-(2-(pyrimidin-4- yl)vinyl)phenyl]azanediyl}diethanol (Compound iii): 1H NMR (MeOD, 600 MHz) delta 9.02 (d, J=1.2 Hz, 1H), 8.61 (d, J= 5.4 Hz, 1H), 7.88 (d, J= 15.6 Hz, 1H), 7.58 (d, J= 8.7 Hz, 2H), 7.53 (dd, J= 6.0, 1.2 Hz, 1H), 6.98 (d, J= 15.6 Hz, 1H), 6.88 (d, J= 8.7 Hz, 2H), 3.71 (t, J= 6.0 Hz, 4H), 3.57 (t, J= 6.0 Hz, 4H); 13C NMR (DMSO-d6, 150 MHz) delta 165.23, 159.17, 157.76, 149.72, 139.99, 130.84, 125.87, 121.64, 119.42, 113.66, 51.36, 50.08; HRMS clcd for C16H19N302+m/z (M+H)+ 286.1550, found 286.1546.
Statistics shows that 3438-46-8 is playing an increasingly important role. we look forward to future research findings about 4-Methylpyrimidine.
Reference:
Patent; TEXAS CHILDREN’S HOSPTIAL; ANNAPRAGADA, Ananth; TANIFUM, Eric A.; SRIVASTAVA, Mayank; (143 pag.)WO2016/57812; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia