Adding a certain compound to certain chemical reactions, such as: 42754-96-1, 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 42754-96-1, blongs to pyrimidines compound. Computed Properties of C5H2Cl2N4
This reaction was run five times with 1 g each batch. The amounts shown are a total of each of the five batches.To a solution of 4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine (compound la) (5 g, 26.5mmol, Chemshuttle) in ACN (100 mL) was added N-bromosuccinimide (5.18 g, 29.1 mmol).The reaction was heated in a microwave at 100 C over 15 minutes. ACN was removed under vacuum. The remaining residue was partitioned between EtOAc (150 mL) and water (300mL H20 + 100 mL NaCI). The aqueous layer was extracted wit EtOAc (150 mL). Organic layers were combined, washed water (100 mL H20 + 20 mL NaCI) X 3, dried over Na2SO4, filteredand evaporated under reduced pressure. The residue was triturated with water (30 mL) x3 and dried in vacuo at 45C to afford a solid 3-bromo-4,6-dichloro-1H-pyrazolo[3,4- d]pyrimidine (compound 1) (6.5 g, 92% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,42754-96-1, its application will become more common.
Reference:
Patent; UNIVERSITY OF DUNDEE; GILBERT, Ian Hugh; THOMAS, Michael George; (37 pag.)WO2016/116752; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia