Extracurricular laboratory: Synthetic route of 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine

Statistics shows that 633328-98-0 is playing an increasingly important role. we look forward to future research findings about 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine.

Synthetic Route of 633328-98-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.633328-98-0, name is 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine, molecular formula is C5H3ClN4, molecular weight is 154.5571, as common compound, the synthetic route is as follows.

Step 1A mixture of of 5 -chioro- 1 H-pyrazolo [4,3 -d]pyrimidine (1 g, 6.47 mmol) and NIS (1.747 g, 7.76 mmol) in acetonitrile (6 mL) in a microwave sealed tube was heated to 120C for 40 mm in an oil bath. Then the reaction was cooled down and concentrated to dryness. The residue was purified via gradient C18 chromatography [ISCO, 0 – 100 % water(0.1% TFA) in acetonitrile(0,1% TFA)] which furnished Intermediate Hi.

Statistics shows that 633328-98-0 is playing an increasingly important role. we look forward to future research findings about 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DEMONG, Duane; GRESHOCK, Thomas, J.; CHANG, Ronald, K.; DAI, Xing; LIU, Hong; MCCAULEY, John, A.; LI, Wei; BASU, Kallol; SCOTT, Jack, D.; MILLER, Michael; WO2015/26683; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia