Related Products of 53557-69-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.53557-69-0, name is 6-Iodopyrimidin-4-amine, molecular formula is C4H4IN3, molecular weight is 221, as common compound, the synthetic route is as follows.
Step 9: 4-(6-Aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1 H-pyrrole-2-carbonitrilento a 50 mL round bottom flask equpped wfth a stir bar, condenser and 3-way vave connected to argon and vacuum 1 -(5-chloro-2-methylphenyl)-4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)-1 H-pyrrole-2-carbonitrile coming from the previous step, 6-iodopyrimidin-4-amine (663 mg, 3.0 mmol), 2M Na2003 (3.0 mL, 6.0 mmol) and dioxane (20 mL) were charged at room temperature. The resuWng reacton mixture was degassed three times back fAhng wfthfour times back flWng wfth argon each time and then warmed to 110 C for 1 h. The reacton mixture was coo?ed to room temperature, fUtered through a pad of Cehte, washed wfth EtOAc, and the fUtrate was concentrated and then dUuted wfth EtOAc and water. The two ayers were separated, and the aqueous ayer was extracted wfth EtOAc, The combned organic fractions were washed wfth aqueous brne, dried over Na2SO4, fNtered and concentrated under reduced pressure. The residue was purified by Biotage SP1 Elash Chromatography (DCM/MeOH/7N NH3 n MeOH95/5/05) to afford the tfte compound (291 mg, 47%, 2 steps).1H NMR (400 MHz, DMSO-d6) 8.33 (d, J = 0.98 Hz, 1 H), 7.96 (d, J = 1.7 Hz, 1 H), 7.64 – 7.69 (m, 2H), 7.55 – 7.61(m, 1H), 7.50-7.54 (m, 1H), 6.81 (s, 2H), 6.65 (d, J = 1.1 Hz, 1H), 2.10 (s, 3H).HRMS (ESI) m/z calcd for C16H12C1N5 + H 310.0854, found 310.0858.
Statistics shows that 53557-69-0 is playing an increasingly important role. we look forward to future research findings about 6-Iodopyrimidin-4-amine.
Reference:
Patent; NERVIANO MEDICAL SCIENCES S.R.L.; BRASCA, Maria Gabriella; BINDI, Simona; CALDARELLI, Marina; NESI, Marcella; ORRENIUS, Sten Christian; PANZERI, Achille; WO2014/19908; (2014); A2;,
Pyrimidine | C4H4N2 – PubChem,
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