The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1074-41-5, name is 6-Amino-2-(methylthio)pyrimidin-4-ol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 6-Amino-2-(methylthio)pyrimidin-4-ol
General procedure: A mixture of 6-amino-2-(alkylthio)pyrimidin-4(3H)-one 5 (1 mmol),1,3-diethyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione 6 (1 mmol),arylaldehyde (1 mmol) and [gamma-Fe2O3HAp-SO3H] (0.05 g) in EtOH (10 mL) was heated under reflux. The progress of the reaction was monitored by TLC (EtOAc/petroleum: 2/1). After completion ofthe reaction, the catalyst was separated from the reaction mixture by external magnet and reused in the next run. The reaction mixture was cooled, and the solid obtained was recrystallised from EtOH/H2O to give the desired pure product. 7- (4 -Chlorophenyl ) – 4 , 5 – dioxo-2- thioxo-1,2 , 3 , 4 , 5,8 -hexahydropyrido[2,3-d]pyrimidine-6-carbonitrile (3a): Cream powder; m.p. >300 C; IR (KBr) (numax/cm-1): 3317, 2190, 1684, 1622,1587, 1535, 1456, 1508, 1195, 812; 1H NMR (400 MHz, DMSO-d6): delta 7.69 (2H, d, J=8.8 Hz, ArH), 7.89 (2H, d, J=8.8 Hz, ArH), 13.19 (1H,s, NH), 13.59 (1H, s, NH) ppm; 13C NMR (100 MHz, DMSO-d6): delta 92.5, 98.5, 115.1, 129.1, 131.1, 135.7, 136.4, 153.8, 163.4, 165.3, 170.8,176.6 ppm. Anal. calcd for C14H7ClN4O2S (330.75): C, 50.84; H, 2.13;N, 16.94; found: C, 50.71; H, 2.03; N, 16.79%.
With the rapid development of chemical substances, we look forward to future research findings about 1074-41-5.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia