Adding a certain compound to certain chemical reactions, such as: 4270-27-3, 6-Chloropyrimidine-2,4(1H,3H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C4H3ClN2O2, blongs to pyrimidines compound. COA of Formula: C4H3ClN2O2
1-Bromo-2-butyne (9.4 mL, 0.11 mol) was added to a mixture of 6-chloropyrimidine-2,4(1H,3H)-dione (14.6 g, 0.1 mol), ethyldiisopropylamine (15 mL, 0.15 mol) and 250 mL of N,N-dimethylformamide. The reaction mixture was stirred overnight at ambient temperature. For work-up, the reaction mixture was diluted with approximately 300 mL of water. The light precipitate formed was suction filtered and washed with water. The filter cake was washed with diethyl ether and dried to give 1-(but-2-yn-1-yl)-6-chloropyrimidine-2,4(1H,3H)-dione (9) as a yellow powder (17 g, yield 85%). 1H NMR (400 MHz, CDCl3) delta 5.91 (s, 1H), 4.75 (d, J = 2.0 Hz, 2H), 1.82 (t, J = 2.0 Hz, 3H). ESI-MS calculated for (C8H8ClN2O2) [M + H]+, 199.03, found 199.0.
The synthetic route of 4270-27-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Xie, Hui; Zeng, Lili; Zeng, Shaogao; Lu, Xin; Zhao, Xin; Zhang, Guicheng; Tu, Zhengchao; Xu, Hongjiang; Yang, Ling; Zhang, Xiquan; Wang, Shanchun; Hu, Wenhui; European Journal of Medicinal Chemistry; vol. 68; (2013); p. 312 – 320;,
Pyrimidine | C4H4N2 – PubChem,
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