672-45-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 672-45-7, name is 2,4-Dihydroxy-6-trifluoromethylpyrimidine, the common compound, a new synthetic route is introduced below.
SYNTHESIS EXAMPLE 20 (2,4-dinitro-6-trifluoromethylphenyl)-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione (compound No. 5.65 of this invention) 1.0 g of 6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione was added to 10 ml of dimethylformamide, followed by addition of 0.65 g of sodium hydride (purity: 55%) with stirring at 0 C. The mixed solution was stirred at room temperature for 30 minutes, then cooled to 0 C. and added dropwise with a 5 ml dimethylformamide solution of 1.89 g of 2-chloro-3,5-dinitrobenzotrifluoride. After the solution was further stirred at room temperature for 3 hours, the solvent was distilled away under reduced pressure. After addition of cooled dilute hydrochloric acid thereto, the residue was extracted with 100 ml of ethyl acetate. The obtained organic layer was dried over anhydrous sodium sulfate and then the solvent was distilled away under reduced pressure to form a crude product. This crude product was recrystallized from a mixed solvent of chloroform and petroleum ether to obtain 0.77 g of the objective compound. M.p.: 219.0~220.5 C. 1 H-NMR (CDCl3 +CD3 OD, TMS, delta ppm): 6.10 (1H,s), 8.78 (1H,d,J=3.0 Hz), 9.08 (1H,d,J=3.0 Hz).
Statistics shows that 672-45-7 is playing an increasingly important role. we look forward to future research findings about 2,4-Dihydroxy-6-trifluoromethylpyrimidine.
Reference:
Patent; Nissan Chemical Industries Ltd.; US5116404; (1992); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia