Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 761440-16-8, name is 2,5-Dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C13H13Cl2N3O2S
2,5-dichloro-N-(2-(isopropylsulfonyl)phenyl)py-rimidine-4-amine (472 mg, i.36 mmol) was dissolved in0.08 M HC1-ethoxyethanol (i .0 mE), to which the compound (200 mg, i . i3 mmol) prepared in preparative example 20 was added, followed by stirring at 80 C. for i2 hours. The reaction mixture was cooled to room temperature, neutralized with sodium hydrogen carbonate aqueous solution, and extracted twice with ethylacetate. The extracted organic layer was dried over sodium sulfate and then filtered. The solvent was eliminated by distillation under reduced pressure. Then, purification was performed by silica gel colunm chromatography (eluent: methanol/ dichioromethane, i/9) to give the target compound 2-(4-((5- chioro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidine- 2-yl)amino)-5-methoxy-2-methylphenyl)acetonitrile as a white solid (450 mg, 0.926 mmol, yield: 8i%).10581] ?H-NMR (300 MHz, CDC13) oe 9.53 (s, br, iH),8.53 (d, J=8.3 Hz, iH), 8.i8 (s, iH), 8.i3 (s, iH), 7.94 (d, J=7.9 Hz, iH), 7.64 (t, J=8.4 Hz, iH), 7.55 (s, br, iH), 7.28 (t, J=7.8 Hz, iH), 6.86 (s, iH), 3.9i (s, 3H), 3.63 (s, 2H), 3.26 (sept, J=6.9 Hz, iH), 2.i7 (s, 3H), i.3i (d, J=6.9 Hz, 6H); EC/MS 485.9 [M+H].
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Reference:
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; Kim, Pilho; Kim, Hyoung Rae; Cho, Sung Yun; Ha, Jae Du; Jung, Hee Jung; Yun, Chang Soo; Hwang, Jong Yeon; Park, Chi Hoon; Lee, Chong Ock; Ahn, Sunjoo; Chae, Chong Hak; (97 pag.)US2018/111905; (2018); A1;,
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