Adding a certain compound to certain chemical reactions, such as: 857641-46-4, 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine, blongs to pyrimidines compound. Recommanded Product: 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine
A solution containing 2-(4-bromo-pyrazol-1-yl)-pyrimidine (300 mg, 1.34 mmol), 4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (280 mg, 1.34 mmol), PdCI2(dppf) (95 mg, 0.13 mmol) and potassium phosphate (800 mg, 4 mmol) in dioxane was heated at 80 C under argon for overnight. After removed the solvent, ethylacetate was added and the mixture was filtered, washed with water.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,857641-46-4, 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; SCHERING CORPORATION; WO2008/153858; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia