Reference of 90213-67-5 ,Some common heterocyclic compound, 90213-67-5, molecular formula is C7H5Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
(2S,3S)-3-Aminobicyclo[2.2.2]octane-2-carboxylic acid ethyl ester hydrochloride(1.26g, 5.40mmol)And 2,4-dichloro-7-methyl-7H-pyrrole[2,3-d]pyrimidine (1.10 g, 5.40 mmol) was dissolved in DMF (5 mL).Add K2CO3 (1.50g, 11.00mmol),The resulting mixture was stirred at room temperature overnight.Water (50 mL) was added to the reaction solution to quench the reaction.The liquid was separated and the aqueous phase was extracted with ethyl acetate (50 mL×2).The combined organic phases were washed with brine (80 mL).Dry with anhydrous sodium sulfate, filter, and distill off the solvent under reduced pressure.The residue was purified by silica gel column chromatographyThe title compound was obtained as a yellow solid (979 mg, 50%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,90213-67-5, its application will become more common.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Tang Changhua; Yin Junjun; Yi Kai; Lei Yibo; Wang Yejun; Zhang Yingjun; (138 pag.)CN108276401; (2018); A;,
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