Synthetic Route of 911461-47-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 911461-47-7, name is 4,6-Dichloropyrimidine-5-carboxamide, molecular formula is C5H3Cl2N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of amine 21 (650 mg, 3.8 mmol), (4,6-dichloropyrimidin-5-yl)formamide (1.21 g, 5.7 mmol; prepared according to a published procedure25), and DIPEA (2.25 mL, 11.4 mmol) in BuOH (20 mL) washeated in a sealed microwave reactor for 2 h at 140 C. The solvent was removed in vacuo and the residue was purified by column chromatography [silica gel (400 g), EtOAc ? EtOAc-toluene-acetone-EtOH (17:4:3:1)] to give a foam; yield: 669 mg (57%).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 911461-47-7, 4,6-Dichloropyrimidine-5-carboxamide.
Reference:
Article; ?ala, Michal; Dejmek, Milan; Prochazkova, Eli?ka; H?ebabecky, Hubert; Ryba?ek, Ji?i; Dra?insky, Martin; Novak, Pavel; Rosenbergova, ?arka; Rosenberg, Ivan; Nencka, Radim; Synthesis; vol. 47; 17; (2015); p. 2654 – 2662;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia