Extracurricular laboratory: Synthetic route of 919116-36-2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 919116-36-2, 4-Chloro-2-(methylthio)-5-(trifluoromethyl)pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference of 919116-36-2, Adding some certain compound to certain chemical reactions, such as: 919116-36-2, name is 4-Chloro-2-(methylthio)-5-(trifluoromethyl)pyrimidine,molecular formula is C6H4ClF3N2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 919116-36-2.

To a reaction vessel charged with 4-chloro-2-(methylthio)-5-(trifluoromethyl)pyrimidine (1.98 g, 8.66 mmol) and sodium iodide (3.89 g, 26.0 mmol) was added hydriodic acid (28 mL, 57 %). The vessel was sealed and the mixture allowed to stir for 48h at rt before being poured into water. The resulting precipitate was collected by vacuum filtration, washed with sat. aq. NaHC03 sol. and dried under vacuum to give the title compound as a pale yellow solid (1.46 g, 53 %). LCMS (Method 1 ) Rt 3.003 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 919116-36-2, 4-Chloro-2-(methylthio)-5-(trifluoromethyl)pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BIONOMICS LIMITED; HARVEY, Andrew John; RIPPER, Justin Anthony; HUFF, Belinda Cheryl; PAUL, Dharam; WO2015/123722; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia