Electric Literature of 93366-88-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 93366-88-2 as follows.
The final product 03 (20 mg, 0.062 mmol), 2-amino-7H-pyrrolo [2,3-d] pyrimidine (25 mg, 0.186 mmol) and Et3N (25 mg, 0.25 mmol) were weighed into a bottle,Add 2 mL of DMF to dissolve the reaction reagent.The reaction was heated at 50 C overnight.The crude reaction product was directly purified by reverse-phase HPLC to obtain the target compound YC124 (18.8 mg).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,93366-88-2, its application will become more common.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhao Yujun; Li Jia; Wang Zengtao; Zhang Shiyan; Zang Yi; Wang Peipei; Sun Dandan; Zhang Hanyan; (155 pag.)CN110818683; (2020); A;,
Pyrimidine | C4H4N2 – PubChem,
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