As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 956034-07-4, name is 2,4-Dichlorofuro[3,2-d]pyrimidine, molecular formula is C6H2Cl2N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2,4-Dichlorofuro[3,2-d]pyrimidine
Weigh 4-hydroxy-3,5-dimethylbenzonitrile (1.5 g, 10 mmol)And potassium carbonate (1.7 g, 12 mmol) in 30 mL of DMF,Stir at room temperature for 15 minutes.Then 2,4-dichlorofuro[3,2-d]pyrimidine 1 (1.9 g, 10 mmol) was addedStirring was continued for 2 h at room temperature (TLC detection was completed).Wait for a lot of white solids to form,Slowly add 100mL of ice water to it.filter,Vacuum drying,Recrystallization from ethanol gave Intermediate 5.White solid,Yield 96%,
With the rapid development of chemical substances, we look forward to future research findings about 956034-07-4.
Reference:
Patent; Shandong University; Liu Xinyong; Kang Dongwei; Zhan Peng; Fang Zengjun; Wang Zhao; (11 pag.)CN108586471; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia