Reference of 372118-67-7 , The common heterocyclic compound, 372118-67-7, name is Pyrimidin-2-ylmethanamine hydrochloride, molecular formula is C5H8ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
5-bromosalicylaldehyde (2.49 mmol) and 2-aminomethylpyrimidine HCl (3.73 mmol) were combined in THF:MeOH (20:2 mL) mixture followed by addition of N,N-diisopropylethylamine (5-7 mmol). The mixture was stirred under N2 at RT for several hours. After the reaction was complete or substantially complete, 1 equiv. of NaBH4 was added and the mixture was stirred at room temperature overnight. The excess hydride was quenched with 1N HCl. The mixture was concentrated to remove most of organic solvents. Water was added and the organic phase was extracted with DCM. The organic phase was concentrated to give A.
The synthetic route of 372118-67-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Kalla, Rao; Perry, Thao; Zablocki, Jeff; US2015/175595; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia