Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Category: pyrimidines.
Farmer, Luc J.;Ledeboer, Mark W.;Hoock, Thomas;Arnost, Michael J.;Bethiel, Randy S.;Bennani, Youssef L.;Black, James J.;Brummel, Christopher L.;Chakilam, Ananthsrinivas;Dorsch, Warren A.;Fan, Bin;Cochran, John E.;Halas, Summer;Harrington, Edmund M.;Hogan, James K.;Howe, David;Huang, Hui;Jacobs, Dylan H.;Laitinen, Leena M.;Liao, Shengkai;Mahajan, Sudipta;Marone, Valerie;Martinez-Botella, Gabriel;McCarthy, Pamela;Messersmith, David;Namchuk, Mark;Oh, Luke;Penney, Marina S.;Pierce, Albert C.;Raybuck, Scott A.;Rugg, Arthur;Salituro, Francesco G.;Saxena, Kumkum;Shannon, Dean;Shlyakter, Dina;Swenson, Lora;Tian, Shi-Kai;Town, Christopher;Wang, Jian;Wang, Tiansheng;Wannamaker, M. Woods;Winquist, Raymond J.;Zuccola, Harmon J. research published 《 Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases》, the research content is summarized as follows. While several therapeutic options exist, the need for more effective, safe, and convenient treatment for a variety of autoimmune diseases persists. Targeting the Janus tyrosine kinases (JAKs), which play essential roles in cell signaling responses and can contribute to aberrant immune function associated with disease, has emerged as a novel and attractive approach for the development of new autoimmune disease therapies. We screened our compound library against JAK3, a key signaling kinase in immune cells, and identified multiple scaffolds showing good inhibitory activity for this kinase. A particular scaffold of interest, the 1H-pyrrolo[2,3-b]pyridine series (7-azaindoles), was selected for further optimization in part on the basis of binding affinity (Ki) as well as on the basis of cellular potency. Optimization of this chem. series led to the identification of VX-509 (decernotinib), a novel, potent, and selective JAK3 inhibitor, which demonstrates good efficacy in vivo in the rat host vs. graft model (HvG). On the basis of these findings, it appears that VX-509 offers potential for the treatment of a variety of autoimmune diseases.
2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., Category: pyrimidines
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia