Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. HPLC of Formula: 109-12-6.
Filho, Eclair Venturini;Pina, Jorge W. S.;Antoniazi, Mariana K.;Loureiro, Laiza B.;Ribeiro, Marcos A.;Pinheiro, Carlos B.;Guimaraes, Celina J.;de Oliveira, Fatima C. E.;Pessoa, Claudia;Taranto, Alex G.;Greco, Sandro J. research published 《 Synthesis, docking, machine learning and antiproliferative activity of the 6-ferrocene/heterocycle-2-aminopyrimidine and 5-ferrocene-1H-pyrazole derivatives obtained by microwave-assisted Atwal reaction as potential anticancer agents》, the research content is summarized as follows. A simple and fast methodol. under microwave irradiation for the synthesis of 2-aminopyrimidines I [R = H, H2N, O2N; R1 = 2-thienyl, 2-phenyltriazol-4-yl, ferrocenyl, etc.] and pyrazole derivatives II [R2 = H, H2N, O2N] using Atwal reaction was reported. After the optimization of the reaction conditions, eight 2-aminopyrimidines I containing ferrocene and heterocycles and three ferrocene pyrazoles II were synthesized from the resp. chalcones in good yields. Eight compounds had their structure determined by X-ray diffraction. The mol. hybrid I and II were tested on four cancer cell lines – HCT116, PC3, HL60 and SNB19 – where four pyrimidines I [R = H, R1 = ferrocenyl; R = H2N, R1 = 2-phenyltriazol-4-yl; R = H, R1 = 1H-pyrrol-2-yl, 2-thienyl] and one pyrazole derivative II [R2 = H2N] showed promising antiproliferative activity. In addition, docking simulation and machine learning methods were carried out to explain the biol. activity achieved by the synthesized compounds
HPLC of Formula: 109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia