Hemilabile MICN铏?/sup> ligands allow oxidant-free Au(I)/Au(III) arylation-lactonization of 绾?alkenoic acids was written by Font, Pau;Valdes, Hugo;Guisado-Barrios, Gregorio;Ribas, Xavi. And the article was included in Chemical Science in 2022.Name: 2-Ethynylpyrimidine This article mentions the following:
Here authors describe the synthesis of two Au(I) complexes bearing bidentate hemilabile MICN铏?/sup> ligands ligands, [AuI(MICN铏?/sup>)Cl], and their ability to stabilize square-planar Au(III) species (MIC = mesoionic carbene). The presence of the hemilabile N-ligand contributed to stabilize the ensuing Au(III) species acting as a five-membered ring chelate upon its coordination to the metal center. The Au(III) complexes can be obtained either by using external oxidants or, alternatively, by means of feasible oxidative addition with strained biphenylene Csp2-Csp2 bonds as well as with aryl iodides. Based on the fundamental knowledge gained on the redox properties on these Au(I)/Au(III) systems, authors successfully develop a novel Au(I)-catalytic procedure for the synthesis of 绾?substituted 绾?butyrolactones through the arylation-lactonization reaction of the corresponding 绾?alkenoic acid. The oxidative addition of the aryl iodide, which in turn is allowed by the hemilabile nature of the MICN铏?/sup> ligand, is an essential step for this transformation. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Name: 2-Ethynylpyrimidine).
2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Name: 2-Ethynylpyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia