Frippiat, Steven team published research on Synlett in 2020 | 4595-59-9

4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., Electric Literature of 4595-59-9

The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Electric Literature of 4595-59-9.

Frippiat, Steven;Peresson, Antoine;Perse, Thibaut;Ramondenc, Yvan;Schneider, Cedric;Querolle, Olivier;Angibaud, Patrick;Poncelet, Virginie;Meerpoel, Lieven;Levacher, Vincent;Bischoff, Laurent;Baudequin, Christine;Hoarau, Christophe research published 《 Pd(0)-Catalyzed Direct Inter- and Intramolecular C-H Functionalization of 4-Carboxyimidazoles》, the research content is summarized as follows. The palladium-catalyzed arylation and alkenylation of N-substituted Me imidazole-4-carboxylates were described through inter- and intramol. pathways. Both direct C2-H and C5-H arylation and alkenylation proceeded under Pd(0)/Cu(I) cooperative catalysis and Pd(0) catalysis, resp., in low-polarity 1,4-dioxane solvent. The methodol. gave access to C2 (hetero)aryl or alkenyl imidazoles as well as innovative C2- and C5-arylated fused imidazoles tricycles with a five- to seven-membered middle ring.

4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., Electric Literature of 4595-59-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia