The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Bromo-3-methoxypropanoic acid(SMILESS: O=C(O)C(Br)COC,cas:65090-78-0) is researched.Quality Control of 5-Methylfuran-2(3H)-one. The article 《New and alternate synthesis of lacosamide with chemoenzymatic method》 in relation to this compound, is published in Journal of Chemical and Pharmaceutical Research. Let’s take a look at the latest research on this compound (cas:65090-78-0).
Lacosamide [(R)-2-acetamido-N-benzyl-3-methoxy propionamide] 5 is a novel antiepileptic drug. Lacosamide was prepared by a chem. method with enzymic resolution of racemic lacosamide. Herein is reported an expedient four-steps enantioselective synthesis of lacosamide 5 beginning with Me 2,3-dibromo propionate 1. A new resolution process catalyzed by Novozyme 435. The products were obtained in very good yields and in a state of high purity. All the newly synthesized compounds (2-5) were characterized by their spectral (IR, 1H NMR, C13 NMR and MS) data.
After consulting a lot of data, we found that this compound(65090-78-0)Quality Control of 2-Bromo-3-methoxypropanoic acid can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia