Gambacorta, Augusto’s team published research in Tetrahedron in 55 | CAS: 608-34-4

Tetrahedron published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C5H6N2O2, Name: 3-Methylpyrimidine-2,4(1H,3H)-dione.

Gambacorta, Augusto published the artcileHSAB driven chemoselectivity in alkylation of uracil derivatives. A high yielding preparation of 3-alkylated and unsymmetrically 1,3-dialkylated uracils, Name: 3-Methylpyrimidine-2,4(1H,3H)-dione, the publication is Tetrahedron (1999), 55(43), 12615-12628, database is CAplus.

A qual. hardness scale (N1<N3<O4) has been found for the conjugated bases of 2-methoxy-4(3H)-pyrimidinone and its 5- and 6-Me derivatives and applied to high yielding chemoselective N3 methylation, ethylation and benzylation reactions. Removal of the 2-methoxy group followed by a second alkylation affords unsym. 1,3-disubstituted uracils.

Tetrahedron published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C5H6N2O2, Name: 3-Methylpyrimidine-2,4(1H,3H)-dione.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia