Aminopyrimidines as electron-rich azadienes: extension of the synthetic potential of hetero Diels-Alder reactions under acidic conditions was written by Garcia, Celeste;Melguizo, Manuel;Cobo, Justo;Sanchez, Adolfo;Nogueras, Manuel;Lopez, Ma Dolores;Low, John N.. And the article was included in Synlett in 2001.SDS of cas: 54030-56-7 This article mentions the following:
By addition of a catalytic amount of a strong acid and selection of the appropriate solvent, the cycloaddition reactions of MeO2CC濡炪倖鑹鹃幐绀怬2Me (DMAD) to 6-pyrimidinamines drastically changed their course leading to pyrrolo[3,4-c]pyridines, while, in the absence of acid, 6-amino-3,4-pyridinedicarboxylates were obtained. This change was interpreted on the basis of acid interception of the non-isolable adducts formed by initial hetero Diels-Alder cycloaddition between the reactants. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7SDS of cas: 54030-56-7).
6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.SDS of cas: 54030-56-7
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia