Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Category: pyrimidines.
Garcia-Garcia, Amalia;Noriega, Lisset;Melendez-Bustamante, Francisco J.;Castro, Maria Eugenia;Sanchez-Gaytan, Brenda L.;Choquesillo-Lazarte, Duane;Gonzalez-Vergara, Enrique;Rodriguez-Dieguez, Antonio research published 《 2-Aminopyrimidinium Decavanadate: Experimental and Theoretical Characterization, Molecular Docking, and Potential Antineoplastic Activity》, the research content is summarized as follows. The interest in decavanadate anions has increased in recent decades, since these clusters show interesting applications as varied as sensors, batteries, catalysts, or new drugs in medicine. Due to the capacity of the interaction of decavanadate with a variety of biol. mols. because of its high neg. charge and oxygen-rich surface, this cluster is being widely studied both in vitro and in vivo as a treatment for several global health problems such as diabetes mellitus, cancer, and Alzheimer′s disease. Here, we report a new decavanadate compound with organic mols. synthesized in an aqueous solution and structurally characterized by elemental anal., IR spectroscopy, thermogravimetric anal., and single-crystal X-ray diffraction. The decavanadate anion was combined with 2-aminopyrimidine to form the compound [2-ampymH]6[V10O28]·5H2O (1). In the crystal lattice, organic mols. are stacked by π-π interactions, with a centroid-to-centroid distance similar to that shown in DNA or RNA mols. Furthermore, computational DFT calculations of Compound 1 corroborate the hydrogen bond interaction between pyrimidine mols. and decavanadate anions, as well as the π-π stacking interactions between the central pyrimidine mols. Finally, docking studies with test RNA mols. indicate that they could serve as other potential targets for the anticancer activity of decavanadate anion.
Category: pyrimidines, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia