Synthesis of amido sulfonamido heteroaromatics under ultrasonication and their antimicrobial activity was written by Gari Divya, Kuppi Reddy;Lakshmi Teja, Gaddam;Yamini, Gudi;Padmaja, Adivireddy;Padmavathi, Venkatapuram. And the article was included in Chemistry & Biodiversity in 2019.Formula: C16H13N3 This article mentions the following:
A convenient and facile methodol. for N-sulfonylation of heteroaryl amines with Et chlorosulfonylacetate in the presence of dispersed sodium in THF under ultrasonication is reported. The corresponding heteroaryl sulfonamido esters are directly condensed with heteroaryl amines to get amido sulfonamido heteroaromatics in the presence of a mild base in THF under ultrasonication. Utilization of easy reaction conditions, shorter reaction times, and isolation of products in high yields under ultrasonication make this process as economically viable. The compounds 12c, 12d, 12f and 13f are potential antibacterial agents against B. subtilis and the compounds 12f, 13c and 13f are potential antifungal agents against A. niger. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Formula: C16H13N3).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Formula: C16H13N3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia