On May 11, 2017, Gaufreteau, Delphine; Kolczewski, Sabine; Plancher, Jean-Marc; Stoll, Theodor published a patent.Related Products of 1209459-32-4 The title of the patent was Preparation of 6-(pyrimidin-2-yl)indolin-2-one derivatives useful in the treatment of CNS-related disorders. And the patent contained the following:
The invention is concerned with indolin-2-one derivatives of formula I that are useful in the treatment of CNS-related diseases. Compounds of formula I wherein A is Ph, pyrazinyl, pyridazinyl, pyrimidinyl, pyridinyl, etc.; R1 and R2 are independently H, lower acyl. cycloalkyl, lower alkyl, etc.; R1R2 may be taken together to form morpholinyl, oxopyrrolidinyl, substituted piperidinyl, etc.; R3 is H and lower alkyl; and pharmaceutically acceptable salts, racemic mixtures, enantiomers, optical isomer and stereoisomers thereof, are claimed. Example compound II was prepared by N-arylation of 3,3-dimethyl-6-(2-methylpyrimidin-5-yl)indolin-2-one with 4-(6-bromopyrazin-2-yl)morpholine. The invention compounds were evaluated for their ENT1 inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of 0.0390 μM. The experimental process involved the reaction of 4-(2-Bromopyrimidin-4-yl)morpholine(cas: 1209459-32-4).Related Products of 1209459-32-4
The Article related to pyrimidinylindolinone preparation treatment cns disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Related Products of 1209459-32-4
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia