The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Related Products of 2927-71-1.
Ge, Yang;Wang, Changyuan;Song, Shijie;Huang, Jiaxin;Liu, Zhihao;Li, Yongming;Meng, Qiang;Zhang, Jianbin;Yao, Jihong;Liu, Kexin;Ma, Xiaodong;Sun, Xiuli research published 《 Identification of highly potent BTK and JAK3 dual inhibitors with improved activity for the treatment of B-cell lymphoma》, the research content is summarized as follows. The BTK and JAK3 receptor tyrosine kinases are two validated and therapeutically amenable targets in the treatment of B-cell lymphomas. Here the authors report the identification of several classes of pyrimidine derivatives as potent BTK and JAK3 dual inhibitors. Among these mols., approx. two thirds displayed strong inhibitory capacity at less than 10 nM concentration, and four compounds could significantly inhibit the phosphorylation of BTK and JAK3 enzymes at concentrations lower than 1 nM. Addnl., these pyrimidine derivatives also exhibited enhanced activity to block the proliferation of B-cell lymphoma cells compared with the representative BTK inhibitor ibrutinib. In particular, two structure-specific compounds I and II displayed stronger activity than reference agents in cell-based evaluation, with IC50 values lower than 10 μM. Further biol. studies, including flow cytometric anal., and a xenograft model for in vivo evaluation, also indicated their efficacy and low toxicity in the treatment of B-cell lymphoma. These findings provide a new insight for the development of novel anti-B-cell lymphoma drugs with multitarget actions.
2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., Related Products of 2927-71-1
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia