《Human spleen dihydroorotate dehydrogenase: a study of inhibition of the enzyme》 was written by Gero, Annette M.; O’Sullivan, William J.; Brown, Desmond. Related Products of 15726-38-2 And the article was included in Biochemical Medicine on August 31 ,1985. The article conveys some information:
Numerous pyrimidine analogs were tested as possible inhibitors of human spleen mitochondrial dihydroorotate dehydrogenase (DHO DHase). Of these, 9 were demonstrated to be effective inhibitors of the enzymic activity. Two compounds, dihydro-5-azaorotate and 6-thiobarbiturate, appeared to be specific inhibitors of the DHO DHase. In addition, 3 compounds, 5-azaorotate, 5-bromoorotate, and barbiturate were also inhibitory against the 2 subsequent enzymes of the pathway, orotate phosphoribosyltransferase and orotidylate decarboxylase, so that they could act against 3 enzymes of the mammalian pyrimidine de novo biosynthetic pathway. In the experiment, the researchers used many compounds, for example, 5-Bromo-4,6-dihydroxypyrimidine(cas: 15726-38-2Related Products of 15726-38-2)
5-Bromo-4,6-dihydroxypyrimidine(cas: 15726-38-2) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Related Products of 15726-38-2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia