The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. HPLC of Formula: 4595-59-9.
Gholinejad, Mohammad;Mirmohammadi, Soheil;Sansano, Jose M. research published 《 Novel Water Dispersible and Magnetically Recoverable Palladium Nano Catalyst for Room-Temperature Suzuki-Miyaura Coupling Reaction》, the research content is summarized as follows. A new magnetic composite comprising starch, imidazolium and triazol groups was used as a support for stabilization of palladium nanoparticles. This material had been characterized by different techniques showing the presence of small and uniform Pd nanoparticles in about 2 nm size. Measuring contact angle confirmed important role of starch on increasing hydrophilic nature of the catalyst. Using 0.05 mol% of this catalyst aryl iodides or bromides reacted with boronic acids at room temperature in aqueous media and the corresponding products were obtained in very good to excellent yields. Hot filtration and PVPy poisoning tests confirmed the heterogeneous nature of the catalyst. E-factor of the catalyst was found in acceptable range and close to green chem. standards This catalyst was magnetically recovered and recycled for 10 consecutive times with small decrease in activity. Also, the robustness of this catalytic system was demonstrated by the characterization of the reused catalyst.
HPLC of Formula: 4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., 4595-59-9.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia