The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. HPLC of Formula: 4595-59-9.
Gholinejad, Mohammad;Esmailoghli, Hamid;Khosravi, Faezeh;Sansano, Jose M. research published 《 Ionic liquid modified carbon nanotube supported palladium nanoparticles for efficient Sonogashira-Hagihara reaction》, the research content is summarized as follows. A palladium supported onto an ionic liquid-modified carbon nanotube was prepared SEM, energy dispersive spectroscopy, thermogravimetric anal., transmission electron microscopy and XPS were used to complete its characterization. The application as catalyst in the copper-free Sonogashira-Hagihara coupling was also studied employing different substrates. This heterogeneous catalyst was successfully recycled for 5 consecutive identical reactions maintaining its efficiency. After this fifth catalytic run the catalyst was characterized again.
HPLC of Formula: 4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., 4595-59-9.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia