Synthesis of 2,4-diamino-6-piperidinylpyrimidine-3-oxide-3′,4′,5′-3H(N) tritiated minoxidil was written by Gilbertson, Terry J.. And the article was included in Journal of Labelled Compounds and Radiopharmaceuticals in 1976.Electric Literature of C4H5ClN4O The following contents are mentioned in the article:
Minoxidil-3′,4′,5′-3H(N), 25.6 Ci/mM, was prepared by reaction of piperidine-3,4,5-3H(N) with 2,4-diamino-6-chloropyrimidine 3-oxide in a sealed tube at 80-90° in the presence of concentrated NH4OH. Purification was by paper chromatog. and the product was suitable for radioimmunoassay and was stable for 6 months in MeOH at 4°. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Electric Literature of C4H5ClN4O).
2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Electric Literature of C4H5ClN4O
35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4