On May 31, 2014, Gimadieva, A. R.; Myshkin, V. A.; Mustafin, A. G.; Chernyshenko, Yu. N.; Borisova, N. S.; Zimin, Yu. S.; Abdrakhmanov, I. B. published an article.Reference of 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Preparation and Antihypoxic Activity of Complexes of Uracil Derivatives with Dicarboxylic Acids. And the article contained the following:
Water-soluble low-toxicity complexes of 6-methyluracil and its derivatives with succinic acid and fumaric acids were prepared The synthesized complexes were tested for anti-hypoxic activity. The title compounds thus formed included butanedioic acid compound with 6-methyl-2,4(1H,3H)-pyrimidinedione (uracil-succinic acid complex), butanedioic acid compound with 5-hydroxy-6-methyl-2,4(1H,3H)-pyrimidinedione (oxymetacil-succinic acid complex), (2E)-2-butenedioic acid compound with 6-methyl-2,4(1H,3H)-pyrimidinedione (uracil-fumaric acid complex). etc. Butanedioic acid compound with 2-ethyl-6-methyl-3-pyridinol (1:1) (mexidol) was used as a reference compound The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Reference of 6-Methylpyrimidine-2,4(1H,3H)-dione
The Article related to succinic fumaric acid uracil complex preparation hypoxia treatment, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Reference of 6-Methylpyrimidine-2,4(1H,3H)-dione
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia